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1996-02-27
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Document 0143
DOCN M9630143
TI Susceptibility of HIV to inactivation by disinfectants and ultraviolet
light.
DT 9603
AU Druce JD; Jardine D; Locarnini SA; Birch CJ; Victorian Infectious
Diseases Reference Laboratory, Fairfield; Hospital, Fairfield,
Australia.
SO J Hosp Infect. 1995 Jul;30(3):167-80. Unique Identifier : AIDSLINE
MED/96131324
AB Assays were developed to assess a variety of conditions and
presentations of infectious HIV to potential inactivating sources. A
range of commercially available disinfectants with active constituents
including glutaraldehyde, chlorine, phenolics, alcohol, iodine and
quaternary ammonium compounds was tested. In addition, u.v. light was
investigated as a potential inactivating source. All products were
assessed against cell-free HIV in culture medium and cell-associated HIV
suspended in medium or whole human blood. All products completely
inactivated cell-free HIV following a 1 min exposure. However,
cell-associated HIV was more resilient, requiring exposure of 5 min or
more for some disinfectants. The effectiveness of the disinfectants was
further compromised in the presence of blood.
DE Blood/VIROLOGY Cell Line Comparative Study Culture Media
Disinfectants/*PHARMACOLOGY Disinfection/*METHODS Human HIV-1/*DRUG
EFFECTS/RADIATION EFFECTS Ultraviolet Rays JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).